{"id":1665,"date":"2023-06-06T19:01:44","date_gmt":"2023-06-06T11:01:44","guid":{"rendered":"http:\/\/www.hngenetics.org\/?p=1665"},"modified":"2023-06-06T19:01:46","modified_gmt":"2023-06-06T11:01:46","slug":"sttt-i-%e4%b8%ad%e5%8d%97%e5%a4%a7%e5%ad%a6%e6%9d%8e%e5%ae%b6%e5%a4%a7%e8%af%be%e9%a2%98%e7%bb%84%e5%90%88%e4%bd%9c%e6%8f%ad%e7%a4%ba%e5%ad%a4%e7%8b%ac%e7%97%87%e8%87%b4%e7%97%85%e6%96%b0%e6%9c%ba","status":"publish","type":"post","link":"http:\/\/www.hngenetics.org\/?p=1665","title":{"rendered":"STTT I \u4e2d\u5357\u5927\u5b66\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u5408\u4f5c\u63ed\u793a\u5b64\u72ec\u75c7\u81f4\u75c5\u65b0\u673a\u5236"},"content":{"rendered":"\n

2023\u5e746\u67085\u65e5\uff0c\u4e2d\u5357\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u533b\u5b66\u9057\u4f20\u5b66\u7814\u7a76\u4e2d\u5fc3\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4<\/a>\u4e0e\u52a0\u62ff\u5927\u5065\u5eb7\u79d1\u5b66\u9662\u5b8b\u4f1f\u5b8f\u9662\u58eb\u56e2\u961f\u5408\u4f5c\u5728\u56fd\u9645\u6743\u5a01\u671f\u520aSignal Transduction and Targeted Therapy<\/em>\uff08IF=38.104\uff09\u5408\u4f5c\u53d1\u8868\u4e86\u9898\u4e3a\u201cCNTNAP2 intracellular domain (CICD) generated by \u03b3-secretase cleavage improves autism-related behaviors\u201d\u7684\u7814\u7a76\u8bba\u6587\uff08PDF\u5168\u6587\u94fe\u63a5<\/a>\uff09\uff0c\u63ed\u793a\u4e86\u5b64\u72ec\u75c7\u98ce\u9669\u57fa\u56e0CNTNAP2<\/em>\u7f3a\u5931\/\u7a81\u53d8\u5bfc\u81f4\u5b64\u72ec\u75c7\u7684\u5206\u5b50\u75c5\u7406\u673a\u5236\u3002<\/p>\n\n\n

\n
\"\"\/<\/figure><\/div>\n\n\n

\u5b64\u72ec\u75c7\u662f\u4e00\u79cd\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u5f71\u54cd\u513f\u7ae5\u5065\u5eb7\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u4e34\u5e8a\u8868\u73b0\u5305\u62ec\u793e\u4f1a\u4ea4\u5f80\u969c\u788d\u3001\u8bed\u8a00\u6c9f\u901a\u969c\u788d\u3001\u5174\u8da3\u8303\u56f4\u72ed\u7a84\u548c\u91cd\u590d\u523b\u677f\u6027\u884c\u4e3a\u3002\u9057\u4f20\u548c\u4e34\u5e8a\u7684\u9ad8\u5ea6\u5f02\u8d28\u6027\u6781\u5927\u5730\u963b\u788d\u4e86\u5bf9\u5176\u75c5\u7406\u673a\u5236\u7684\u8ba4\u8bc6\uff0c\u5176\u53d1\u75c5\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u3002\u9057\u4f20\u56e0\u7d20\u5728\u5b64\u72ec\u75c7\u7684\u53d1\u751f\u4e2d\u8d77\u5230\u5341\u5206\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u76ee\u524d\u5df2\u7ecf\u62a5\u9053\u4e86\u6570\u767e\u4e2a\u5b64\u72ec\u75c7\u76f8\u5173\u57fa\u56e0\uff0c\u5176\u4e2d\uff0c\u63a5\u89e6\u86cb\u767d\u76f8\u5173\u86cb\u767d\u68372\u7684\u7f16\u7801\u57fa\u56e0\uff08Contactin-associated protein-like 2<\/em>\uff0cCNTNAP2<\/em>\uff09\u662f\u4e00\u4e2a\u88ab\u5e7f\u6cdb\u9a8c\u8bc1\u7684\u5b64\u72ec\u75c7\u6613\u611f\u57fa\u56e0\uff0c\u5176\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\uff08Cntnap2<\/em>-\/-<\/sup><\/em>\uff09\u4e5f\u8868\u73b0\u51fa\u5b64\u72ec\u75c7\u6838\u5fc3\u75c7\u72b6\uff0c\u5e38\u7528\u4e8e\u5b64\u72ec\u75c7\u6cbb\u7597\u65b0\u65b9\u6cd5\u53ca\u76f8\u5173\u836f\u7269\u7684\u5f00\u53d1\uff0c\u4f46CNTNAP2<\/em>\u7f3a\u5931\/\u7a81\u53d8\u5bfc\u81f4\u5b64\u72ec\u75c7\u7684\u5206\u5b50\u673a\u5236\u5c1a\u4e0d\u660e\u4e86\u3002<\/p>\n\n\n\n

\u8bb8\u591a\u2160\u578b\u8de8\u819c\u86cb\u767d\uff08\u4f8b\u5982Notch\u3001APP\u7b49\uff09\u90fd\u7ecf\u5386\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u526a\u5207\uff0c\u4ea7\u751f\u7ec6\u80de\u5916\u7247\u6bb5\u548c\u7ec6\u80de\u5185\u7ed3\u6784\u57df\uff0c\u8fdb\u4e00\u6b65\u884c\u4f7f\u5176\u751f\u7269\u5b66\u529f\u80fd\u3002CNTNAP2\u86cb\u767d\u5b9a\u4f4d\u4e8e\u795e\u7ecf\u5143\u7a81\u89e6\u540e\u819c\uff0c\u5c5e\u4e8e\u7a81\u89e6\u7c98\u9644\u5206\u5b50\uff08Neurexins\uff09\u8d85\u5bb6\u65cf\uff0c\u662f\u4e00\u4e2a\u5178\u578b\u7684\u591a\u7ed3\u6784\u57df\u2160\u578b\u8de8\u819c\u86cb\u767d\u3002\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5e8f\u5217\u5206\u6790\u53d1\u73b0CNTNAP2\u4e0eAPP\u7684\u8de8\u819c\u533a\u6c28\u57fa\u9178\u5e8f\u5217\u6709\u9ad8\u5ea6\u7684\u76f8\u4f3c\u6027\uff0c\u4e14\u5305\u542b\u4e00\u4e2a\u4e0eAPP\u7684\u03b3-\u5206\u6ccc\u9176\u8bc6\u522b\u4f4d\u70b9\u5341\u5206\u76f8\u4f3c\u7684\u5e8f\u5217\uff08VVIF\/VVIA\uff0c\u5982\u4e0b\u56fe\uff09\u3002\u6b64\u5916\uff0cCNTNAP2\u53ef\u4ee5\u4e0e\u86cb\u767d\u6c34\u89e3\u9176ADAM\u5bb6\u65cf\uff08ADAM22\u3001ADAM23\u3001ADAM11\uff09\u3001LGI\u5bb6\u65cf\u6210\u5458\u4ee5\u53caMAGUKs\uff08DLGs\u548cMPPs\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u63d0\u793aCNTNAP2\u4e5f\u53ef\u80fd\u7ecf\u5386\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u526a\u5207\uff0c\u91ca\u653e\u80de\u5916\u53ca\u80de\u5185\u7ed3\u6784\u57df\u884c\u4f7f\u751f\u7269\u5b66\u529f\u80fd\u3002<\/p>\n\n\n

\n
\"\"\/<\/figure><\/div>\n\n\n

\u56fe1. CNTNAP2\u86cb\u767d\u7684\u57fa\u672c\u7ed3\u6784\u53ca\u4e0eAPP\u8de8\u819c\u533a\u6c28\u57fa\u9178\u5e8f\u5217\u6bd4\u5bf9\u56fe<\/strong><\/p>\n\n\n\n

\u7814\u7a76\u4eba\u5458\u7ecf\u8fc7\u7cfb\u7edf\u5206\u6790\u53d1\u73b0\uff0cCNTNAP2\u7ecf\u5386\u4e86\u4e24\u6b21\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u526a\u5207\u8fc7\u7a0b\uff0c\u6700\u521d\u5728\u7ec6\u80de\u5916\u533a\u57df\u7ecf\u5386\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u7b2c\u4e00\u6b21\u526a\u5207\u8fc7\u7a0b\uff0c\u751f\u6210\u53ef\u6eb6\u6027\u7684\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u548c\u819c\u951a\u5b9a\u7684C\u672b\u7aef\u7247\u6bb5\uff08CTF\uff09\uff0cCTF\u88ab\u03b3-\u5206\u6ccc\u9176\u8fdb\u4e00\u6b65\u526a\u5207\uff0c\u91ca\u653e\u5176\u80de\u5185\u7ed3\u6784\u57df\uff08CNTNAP2intracellular domain\uff0cCICD\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u5c0f\u9f20\u524d\u989d\u53f6\u76ae\u5c42\u5b9a\u4f4d\u6ce8\u5c04\u817a\u76f8\u5173\u75c5\u6bd2\u8fc7\u8868\u8fbeCICD\uff0c\u53ef\u4ee5\u5b8c\u5168\u633d\u6551Cntnap2<\/em>-\/-<\/sup><\/em>\u5c0f\u9f20\u7684\u793e\u4ea4\u7f3a\u9677\u3001\u91cd\u590d\u523b\u677f\u884c\u4e3a\u7b49\u5b64\u72ec\u75c7\u6838\u5fc3\u8868\u578b\uff0c\u63d0\u793aCICD\u5728\u5b64\u72ec\u75c7\u76f8\u5173\u884c\u4e3a\u4e2d\u8d77\u5230\u5173\u952e\u7684\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0cCICD\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u67d0\u4e9b\u8f6c\u5f55\u56e0\u5b50\uff08\u5982CASK\uff09\u7684\u5165\u6838\uff0c\u8fdb\u4e00\u6b65\u8c03\u8282Necdin<\/em>\u7b49\u4e0b\u6e38\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u5f71\u54cd\u795e\u7ecf\u5143\u53d1\u80b2\u3001\u795e\u7ecf\u5143\u7535\u6d3b\u52a8\uff0c\u53c2\u4e0e\u5b64\u72ec\u75c7\u76f8\u5173\u884c\u8868\u578b\u4e3a\u7684\u8c03\u63a7\u3002<\/p>\n\n\n

\n
\"\"\/<\/figure><\/div>\n\n\n

\u56fe2. CNTNAP2\u5728\u5b64\u72ec\u75c7\u76f8\u5173\u884c\u4e3a\u4e2d\u53d1\u6325\u4f5c\u7528\u7684\u6f5c\u5728\u673a\u5236\u793a\u610f\u56fe<\/strong><\/p>\n\n\n\n

\u8be5\u7814\u7a76\u53d1\u73b0\u4e86CNTNAP2\u7ecf\u5386\u86cb\u767d\u9176\u4ecb\u5bfc\u7684\u526a\u5207\u8fc7\u7a0b\uff0c\u5e76\u9610\u660e\u4e86\u8be5\u8fc7\u7a0b\u7684\u8c03\u63a7\u673a\u5236\u53ca\u751f\u7406\u529f\u80fd\uff0c\u63ed\u793a\u4e86CNTNAP2\u7684\u526a\u5207\u4ea7\u7269CICD\u5728\u5b64\u72ec\u75c7\u76f8\u5173\u884c\u4e3a\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u5c06\u4e09\u4e2a\u5b64\u72ec\u75c7\u6613\u611f\u57fa\u56e0CNTNAP2<\/em>\u3001Necdin<\/em>\u548cCASK<\/em>\u8054\u7cfb\u8d77\u6765\uff0c\u5f3a\u8c03\u4e86\u5b83\u4eec\u53ef\u80fd\u901a\u8fc7\u5171\u540c\u9014\u5f84\u53c2\u4e0e\u5b64\u72ec\u75c7\u76f8\u5173\u884c\u4e3a\u7684\u8c03\u63a7\u3002\u8fd9\u9879\u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u8c03\u63a7\u901a\u8def\u53ef\u80fd\u662fCNTNAP2<\/em>\u7a81\u53d8\/\u7f3a\u5931\u5bfc\u81f4\u5b64\u72ec\u75c7\u53d1\u751f\u7684\u6f5c\u5728\u5206\u5b50\u673a\u5236\uff0c\u4e3a\u5b64\u72ec\u75c7\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u65b0\u7b56\u7565\u3002<\/p>\n\n\n\n

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