{"id":1788,"date":"2025-09-02T10:15:29","date_gmt":"2025-09-02T02:15:29","guid":{"rendered":"http:\/\/www.hngenetics.org\/?p=1788"},"modified":"2025-09-02T10:17:03","modified_gmt":"2025-09-02T02:17:03","slug":"%e4%b8%ad%e5%8d%97%e5%a4%a7%e5%ad%a6%e6%9d%8e%e5%ae%b6%e5%a4%a7%e8%af%be%e9%a2%98%e7%bb%84%e6%8f%ad%e7%a4%ba%e8%87%aa%e9%97%ad%e7%97%87%e7%a4%be%e4%ba%a4%e9%9a%9c%e7%a2%8d%e7%9a%84%e9%81%97%e4%bc%a0","status":"publish","type":"post","link":"http:\/\/www.hngenetics.org\/?p=1788","title":{"rendered":"\u4e2d\u5357\u5927\u5b66\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u63ed\u793a\u81ea\u95ed\u75c7\u793e\u4ea4\u969c\u788d\u7684\u9057\u4f20\u8c03\u63a7\u65b0\u673a\u5236"},"content":{"rendered":"\n<p>2025\u5e748\u670830\u65e5\uff0c\u4e2d\u5357\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u533b\u5b66\u9057\u4f20\u5b66\u7814\u7a76\u4e2d\u5fc3\u3001\u4eba\u7c7b\u91cd\u5927\u75be\u75c5\u52a8\u7269\u6a21\u578b\u7814\u7a76\u6e56\u5357\u7701\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u5728\u56fd\u9645\u6743\u5a01\u671f\u520a<strong><em>Molecular Psychiatry<\/em><\/strong>\uff08\u300a\u5206\u5b50\u7cbe\u795e\u75c5\u5b66\u300b\uff0c \u4e2d\u79d1\u96621\u533a\uff0cIF=10.1\uff09\u5728\u7ebf\u53d1\u8868\u9898\u4e3a<strong>\u201cLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP\u201d (Necdin\u57fa\u56e0\u7f3a\u5931\u901a\u8fc7\u5f71\u54cdSynGAP\u7684\u7a33\u5b9a\u6027\u5bfc\u81f4\u793e\u4ea4\u969c\u788d\u548c\u7a81\u89e6\u529f\u80fd\u5f02\u5e38)<\/strong>\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u63ed\u793a\u4e86\u5c0f<a>\u80d6\u5a01\u5229\u7efc\u5408\u5f81<\/a>\uff08Prader-Willi Syndrome, PWS\uff09\u76f8\u5173\u86cb\u767dNecdin\u53ef\u901a\u8fc7\u7a33\u5b9a\u81ea\u95ed\u75c7\u5173\u952e\u86cb\u767dSynGAP\u53c2\u4e0e\u793e\u4ea4\u884c\u4e3a\u7684\u8c03\u63a7\uff0c\u4e3a\u7406\u89e3\u81ea\u95ed\u75c7\u7684\u75c5\u7406\u673a\u5236\u63d0\u4f9b\u4e86\u91cd\u8981\u7ebf\u7d22\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"830\" height=\"253\" src=\"http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72471.png\" alt=\"\" class=\"wp-image-1790\" srcset=\"http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72471.png 830w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72471-300x91.png 300w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72471-768x234.png 768w\" sizes=\"auto, (max-width: 830px) 100vw, 830px\" \/><\/figure><\/div>\n\n\n<p>\u5c0f\u80d6\u5a01\u5229\u7efc\u5408\u5f81\uff08PWS\uff09\u662f\u4e00\u79cd\u753115\u53f7\u67d3\u8272\u4f53\u957f\u81c2\uff0815q11\u201313\uff09\u533a\u57df\u5f02\u5e38\u5bfc\u81f4\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u75be\u75c5\u3002\u60a3\u8005\u5e38\u8868\u73b0\u4e3a\u808c\u5f20\u529b\u4f4e\u4e0b\u3001\u8fc7\u5ea6\u8fdb\u98df\u3001\u80a5\u80d6\u548c\u6027\u817a\u529f\u80fd\u51cf\u9000\uff0c\u5176\u4e2d\u7ea620\u201330%\u7684\u60a3\u8005\u4f34\u968f\u81ea\u95ed\u75c7\u76f8\u5173\u8868\u578b\u3002\u7136\u800c\uff0cPWS\u60a3\u8005\u81ea\u95ed\u75c7\u6837\u884c\u4e3a\u7684\u5206\u5b50\u673a\u5236\u5c1a\u4e0d\u660e\u4e86\u3002<\/p>\n\n\n\n<p>\u5728\u524d\u671f\u7814\u7a76\u4e2d\uff0c\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u4e0e\u74ef\u6c5f\u5b9e\u9a8c\u5ba4\u5b8b\u4f1f\u5b8f\u9662\u58eb\u5408\u4f5c\uff0c\u63ed\u793a\u4e86\u81ea\u95ed\u75c7\u76f8\u5173\u86cb\u767dCNTNAP2\u7ecf\u03b3-\u5206\u6ccc\u9176\u5207\u5272\u4ea7\u751f\u7684C\u7aef\u7247\u6bb5\uff08CICD\uff09\u53ef\u4fc3\u4f7fCASK\u5165\u6838\uff0c\u8fdb\u800c\u6fc0\u6d3bPWS\u76f8\u5173\u57fa\u56e0Necdin\u7684\u8f6c\u5f55\uff1b\u800c\u4e14\u5728\u524d\u989d\u53f6\u76ae\u5c42\u4e2d\u8fc7\u8868\u8fbeNecdin\u80fd\u6539\u5584Cntnap2\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684\u793e\u4ea4\u7f3a\u9677\u3002<a href=\"http:\/\/www.hngenetics.org\/?p=1715\" data-type=\"post\" data-id=\"1715\">\u4e2d\u5357\u5927\u5b66\u674e\u5bb6\u5927\u6559\u6388\u5408\u4f5c\u53d1\u73b0CNTNAP2\u7a81\u53d8\u5bfc\u81f4\u5b64\u72ec\u75c7\u7684\u65b0\u673a\u5236<\/a><a href=\"http:\/\/www.hngenetics.org\/?p=1665\" data-type=\"post\" data-id=\"1665\"> <\/a><a href=\"http:\/\/www.hngenetics.org\/?p=1665\" data-type=\"post\" data-id=\"1665\">STTT I \u4e2d\u5357\u5927\u5b66\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u5408\u4f5c\u63ed\u793a\u5b64\u72ec\u75c7\u81f4\u75c5\u65b0\u673a\u5236<\/a><\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u7684\u7ed3\u679c\u53d1\u73b0\uff0c<em>Necdin<\/em>\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u8868\u73b0\u51fa\u660e\u663e\u7684\u793e\u4ea4\u7f3a\u9677\uff0c\u5e76\u4f34\u968f\u524d\u989d\u53f6\u76ae\u5c42\u7a81\u89e6\u6570\u91cf\u5f02\u5e38\u589e\u52a0\uff0cmEPSC\u9891\u7387\u548c\u5e45\u5ea6\u663e\u8457\u5347\u9ad8\u3002\u5206\u5b50\u673a\u5236\u7814\u7a76\u8868\u660e\uff0cNecdin\u4e0e\u81ea\u95ed\u75c7\u5173\u952e\u86cb\u767dSynGAP\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7SGT1\u2013HSP90\u5206\u5b50\u4f34\u4fa3\u673a\u5236\u7a33\u5b9aSynGAP\u86cb\u767d\uff0c\u4ece\u800c\u7ef4\u6301\u7a81\u89e6\u529f\u80fd\u5e73\u8861\u3002\u5728<em>Necdin<\/em>\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u4e2d\uff0cSynGAP\u86cb\u767d\u6c34\u5e73\u4e0b\u964d\uff0c\u800c\u5728\u524d\u989d\u53f6\u76ae\u5c42\u8fc7\u8868\u8fbeSynGAP\u80fd\u591f\u6539\u5584\u5176\u7a81\u89e6\u4e0e\u793e\u4ea4\u7f3a\u9677\u3002\u8be5\u6210\u679c\u4e0d\u4ec5\u9610\u660e\u4e86Necdin\u7f3a\u5931\u5bfc\u81f4\u793e\u4ea4\u969c\u788d\u7684\u5206\u5b50\u548c\u795e\u7ecf\u751f\u7269\u5b66\u673a\u5236\uff0c\u800c\u4e14\u63ed\u793a\u4e86SynGAP\u86cb\u767d\u7a33\u6001\u8c03\u63a7\u7684\u65b0\u673a\u5236\u53ca\u5176\u5728\u81ea\u95ed\u75c7\u53d1\u751f\u4e2d\u7684\u91cd\u8981\u610f\u4e49\uff0c\u4e3a\u672a\u6765\u81ea\u95ed\u75c7\u7684\u9776\u5411\u6cbb\u7597\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"345\" src=\"http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473-1024x345.jpg\" alt=\"\" class=\"wp-image-1792\" srcset=\"http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473-1024x345.jpg 1024w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473-300x101.jpg 300w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473-768x259.jpg 768w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473-1536x518.jpg 1536w, http:\/\/www.hngenetics.org\/wp-content\/uploads\/2025\/09\/\u56fe\u72473.jpg 1720w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p>\u4e2d\u5357\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u201c\u672c-\u7855-\u535a\u8fde\u8bfb\u201d\u7814\u7a76\u751f\u674e\u7965\u5b87\u548c\u7855\u58eb\u751fIbrahim Bader\uff08\u5df4\u52d2\u65af\u5766\u7559\u5b66\u751f\uff09\u4e3a\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u4e2d\u5357\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u674e\u5bb6\u5927\u6559\u6388\u3001\u4e2d\u5357\u5927\u5b66\u5b9e\u9a8c\u52a8\u7269\u5b66\u90e8\u5f20\u7ade\u52a9\u7406\u7814\u7a76\u5458\u3001\u5357\u534e\u5927\u5b66\u513f\u79d1\u7f55\u89c1\u75c5\u6559\u80b2\u90e8\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u5218\u5316\u8776\u6559\u6388\u4e3a\u8be5\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6e56\u5357\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6e56\u5357\u7701\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u7684\u652f\u6301\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<a href=\"https:\/\/rdcu.be\/eDbm2\">https:\/\/rdcu.be\/eDbm2<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>2025\u5e748\u670830\u65e5\uff0c\u4e2d\u5357\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u533b\u5b66\u9057\u4f20 <a class=\"mh-excerpt-more\" href=\"http:\/\/www.hngenetics.org\/?p=1788\" title=\"\u4e2d\u5357\u5927\u5b66\u674e\u5bb6\u5927\u8bfe\u9898\u7ec4\u63ed\u793a\u81ea\u95ed\u75c7\u793e\u4ea4\u969c\u788d\u7684\u9057\u4f20\u8c03\u63a7\u65b0\u673a\u5236\">[\u8be6\u7ec6]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":1790,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,9],"tags":[],"class_list":["post-1788","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-17","category-9"],"_links":{"self":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/1788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1788"}],"version-history":[{"count":1,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/1788\/revisions"}],"predecessor-version":[{"id":1793,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/1788\/revisions\/1793"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/media\/1790"}],"wp:attachment":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1788"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1788"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}