{"id":982,"date":"2018-12-26T09:48:53","date_gmt":"2018-12-26T01:48:53","guid":{"rendered":"http:\/\/www.hngenetics.org\/?p=982"},"modified":"2019-06-04T23:04:33","modified_gmt":"2019-06-04T15:04:33","slug":"%e7%a0%94%e7%a9%b6%e5%8f%91%e7%8e%b0%e5%ad%a4%e7%8b%ac%e7%97%87%e7%9a%84%e7%bd%95%e8%a7%81%e5%8f%98%e5%bc%82%e5%a4%9a%e5%9f%ba%e5%9b%a0%e9%81%97%e4%bc%a0%e6%a8%a1%e5%bc%8f%e5%8f%8a%e6%96%b0%e7%9a%84","status":"publish","type":"post","link":"http:\/\/www.hngenetics.org\/?p=982","title":{"rendered":"\u7814\u7a76\u53d1\u73b0\u5b64\u72ec\u75c7\u7684\u7f55\u89c1\u53d8\u5f02\u591a\u57fa\u56e0\u9057\u4f20\u6a21\u5f0f\u53ca\u65b0\u7684\u98ce\u9669\u57fa\u56e0"},"content":{"rendered":"

\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\uff08Autism Spectrum Disorder, ASD\uff09\u662f\u4e00\u7c7b\u5177\u6709\u9ad8\u53d1\u75c5\u7387\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u75be\u75c5\u3002\u6b27\u7f8e\u4eba\u7fa4\u7684\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7814\u7a76\u4ece\u65b0\u53d1\u7a81\u53d8\u89d2\u5ea6\u53d1\u73b0\u5927\u91cf\u5b64\u72ec\u75c7\u9ad8\u98ce\u9669\u57fa\u56e0\u548c\u5019\u9009\u57fa\u56e0\uff0c\u7136\u800c\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5f02\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u7684\u53d1\u751f\u9891\u7387\u4ee5\u53ca\u8868\u73b0\u5ea6\u548c\u5916\u663e\u7387\u5c1a\u672a\u5f97\u5230\u7cfb\u7edf\u7814\u7a76\u3002\u4e2d\u5357\u5927\u5b66\u590f\u6606-\u90ed\u8f89\u8bfe\u9898\u7ec4\u8fd1\u671f\u5728Molecular Autism\u62a5\u9053\u4e86ASD\u9ad8\u98ce\u9669\u57fa\u56e0\u5728\u4e2d\u56fd\u4eba\u7fa4ASD\u60a3\u8005\u4e2d\u7684\u5206\u5e03\u3002\u8be5\u7814\u7a76\u540c\u65f6\u8fd8\u53d1\u73b0\u4e86ASD\u7f55\u89c1\u53d8\u5f02\u7684\u591a\u57fa\u56e0\u9057\u4f20\u6a21\u5f0f\u53ca\u65b0\u7684\u98ce\u9669\u57fa\u56e0\u3002<\/p>\n

\u4e2d\u5357\u5927\u5b66\u590f\u6606<\/a>\u7814\u7a76\u56e2\u961f\u7ecf\u8fc7\u4e0e\u56fd\u5185\u591a\u4e2a\u4e34\u5e8a\u4e2d\u5fc3\u5408\u4f5c\u5efa\u7acb\u4e86\u4e2d\u56fd\u4eba\u7fa4\u5b64\u72ec\u75c7\u4e34\u5e8a\u4e0e\u9057\u4f20\u8d44\u6e90\u6837\u672c\u5e93\uff08ACGC\uff09\uff0c\u76ee\u524d\u5df2\u7ecf\u6709\u8fd15000\u4e2a\u5bb6\u5ead\u53c2\u4e0e\u8be5\u8d44\u6e90\u5e93\u7684\u5efa\u8bbe\u3002\u4e3a\u4e86\u63a2\u7d22\u5728\u6b27\u7f8e\u4eba\u7fa4ASD\u60a3\u8005\u4e2d\u53d1\u73b0\u7684\u9ad8\u98ce\u9669\u57fa\u56e0\u53d8\u5f02\u5728\u4e2d\u56fd\u4eba\u7fa4ASD\u60a3\u8005\u4e2d\u7684\u53d1\u751f\u9891\u7387\u4ee5\u53ca\u8868\u73b0\u5ea6\u548c\u5916\u663e\u7387\uff0c\u590f\u6606\u56e2\u961f\u5229\u7528\u9ad8\u901a\u91cf\u5019\u9009\u6355\u83b7\u6d4b\u5e8f\u5206\u4e24\u671f\u5bf9ACGC\u4e2d\u7ea63000\u4f8b\u60a3\u8005\u8fdb\u884c\u7ea6200\u4e2a\u9ad8\u98ce\u9669\u6216\u5019\u9009\u57fa\u56e0\u7684\u7a81\u53d8\u7b5b\u67e5\u3002\u57282016\u5e74\u5b8c\u6210\u7684\u7b2c\u4e00\u671f\u7814\u7a76\u4e2d\uff08Wang et al. 2016. Nat Commun<\/a>\uff09\u9274\u5b9a\u5e76\u660e\u786e\u4e86\u591a\u4e2a\u9ad8\u98ce\u9669\u81f4\u75c5\u57fa\u56e0\uff0c\u5e76\u53d1\u73b0\u8fd9\u4e9b\u9ad8\u98ce\u9669\u57fa\u56e0\u7684\u65b0\u53d1\u7a81\u53d8\u5728\u6b27\u7f8e\u4eba\u7fa4\u548c\u4e2d\u56fd\u4eba\u7fa4\u6837\u672c\u4e2d\u5e76\u4e0d\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u5728\u8fd1\u671f\u53d1\u8868\u7684\u7b2c\u4e8c\u671f\u7814\u7a76\u4e2d\uff08Guo et al. 2018. Mol Autism<\/a>\uff09\u6574\u5408\u4e86\u4e24\u671f\u51713000\u4e2a\u6837\u672c\u7684\u6d4b\u5e8f\u6570\u636e\u53d1\u73b02\u4e2a\u65b0\u7684ASD\u9ad8\u98ce\u9669\u57fa\u56e0\uff08ZNF292\uff0cRALGAPB\uff09\uff0c\u540c\u65f6\u53d1\u73b0\u591a\u4e2a\u9ad8\u98ce\u9669\u57fa\u56e0\u7684\u81f4\u75c5\u7a81\u53d8\u9057\u4f20\u81ea\u201c\u6b63\u5e38\u201d\u8868\u578b\u7684\u7236\u6bcd\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\u57283000\u4f8b\u60a3\u8005\u4e2d\u53d1\u73b08\u4f8b\uff080.27%\uff09\u60a3\u8005\u643a\u5e26CHD8\u529f\u80fd\u7f3a\u5931\u53d8\u5f02\uff0c\u5176\u4e2d\u8fd1\u4e00\u534a\uff08n = 3\uff09\u7684\u529f\u80fd\u7f3a\u5931\u6027\u7a81\u53d8\u9057\u4f20\u81ea\u201c\u6b63\u5e38\u201d\u8868\u578b\u7684\u7236\u6bcd\u3002\u901a\u8fc7\u5bf9\u7236\u6bcd\u4eb2\u7684\u4e34\u5e8a\u56de\u8bbf\u548c\u8868\u578b\u8bc4\u4f30\uff0c\u53d1\u73b0\u7236\u6bcd\u4eb2\u643a\u5e26\u8005\u5177\u6709\u4f4e\u4e8e\u6b63\u5e38\u4eba\u7fa4\u5e73\u5747\u6c34\u5e73\u7684\u8ba4\u77e5\u529f\u80fd\u548c\u7a0b\u5ea6\u8f83\u8f7b\u7684\u5b64\u72ec\u75c7\u884c\u4e3a\u8868\u578b\u3002<\/p>\n

\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\u90e8\u5206\u60a3\u8005\u540c\u65f6\u643a\u5e26\u591a\u4e2a\u98ce\u9669\u57fa\u56e0\u7684\u7f55\u89c1\u6216\u65b0\u53d1\u7a81\u53d8\uff0c\u63d0\u793aASD\u7684\u7f55\u89c1\u53d8\u5f02\u7684\u591a\u57fa\u56e0\u9057\u4f20\u6a21\u5f0f\u3002\u8fdb\u4e00\u6b65\u901a\u8fc7\u5bf9~2500\u4f8b\u7f8e\u56fdSSC\u5bb6\u7cfb\u7684\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u6570\u636e\u5206\u6790\uff0c\u53d1\u73b0\u643a\u5e26\u591a\u4e2a\u65b0\u53d1\u53d8\u5f02\u7684\u5b64\u72ec\u75c7\u60a3\u8005\u76f8\u6bd4\u6b63\u5e38\u8868\u578b\u7684\u540c\u80de\u5bf9\u663e\u8457\u5347\u9ad8\uff0c\u800c\u4e14\u643a\u5e26\u591a\u4e2a\u65b0\u53d1\u7a81\u53d8\u7684\u60a3\u8005\u4e34\u5e8a\u8868\u578b\u76f8\u6bd4\u643a\u5e26\u5355\u4e2a\u6216\u4e0d\u643a\u5e26\u65b0\u53d1\u7a81\u53d8\u7684\u60a3\u8005\u66f4\u4e3a\u4e25\u91cd\u3002\u8fd9\u4e00\u53d1\u73b0\u5728\u8fd1\u671f\u53d1\u8868\u7684\u53e6\u4e00\u9879\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u4e34\u5e8a\u8bca\u65ad\u5e94\u7528\u7814\u7a76\u8bba\u6587\uff08Guo et al. 2018. Genet Med<\/a>\uff09\u4e2d\u5f97\u5230\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff08\u590f\u6606\u56e2\u961f\u90ed\u8f89\u526f\u7814\u7a76\u5458\u4e0e\u534e\u76db\u987f\u5927\u5b66Evan Eichler<\/a>\u6559\u6388\u5408\u4f5c\u5b8c\u6210\u8be5\u9879\u7814\u7a76\uff09\u3002<\/p>\n

\u8fd9\u4e9b\u53d1\u73b0\u8fdb\u4e00\u6b65\u8868\u660e\u4e86\u5b64\u72ec\u75c7\u9057\u4f20\u7ed3\u6784\u7684\u590d\u6742\u6027\uff0c\u4e3aASD\u7684\u9057\u4f20\u8bca\u65ad\u548c\u9057\u4f20\u54a8\u8be2\u63d0\u51fa\u4e86\u66f4\u591a\u7684\u6311\u6218\u3002\u8fd9\u4e9b\u7814\u7a76\u4e5f\u540c\u65f6\u63d0\u793a\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u4f1a\u6210\u4e3a\u5728\u4e2a\u4f53\u6c34\u5e73\u5168\u9762\u9274\u5b9aASD\u7684\u98ce\u9669\u53d8\u5f02\u5e76\u8fdb\u884c\u65e9\u671f\u9884\u8b66\u7684\u91cd\u8981\u624b\u6bb5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\uff08Autism Spectrum D [\u8be6\u7ec6]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":808,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,9],"tags":[],"class_list":["post-982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rp","category-9"],"_links":{"self":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=982"}],"version-history":[{"count":2,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/982\/revisions"}],"predecessor-version":[{"id":984,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/posts\/982\/revisions\/984"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=\/wp\/v2\/media\/808"}],"wp:attachment":[{"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=982"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.hngenetics.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}